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 | |
| 臨床資料 | |
|---|---|
| 商品名 | Circlet, Implanon, Nexplanon, others |
| 其他名稱 | ORG-3236; SCH-900702 (with EE); 3-Ketodesogestrel; 3-Oxodesogestrel; 11-Methylenelevonorgestrel;[1] 11-Methylene-17α-ethynyl-18-methyl-19-nortestosterone; 11-Methylene-17α-ethynyl-18-methylestr-4-en-17β-ol-3-one |
| AHFS/Drugs.com | 专业药物信息 |
| MedlinePlus | a604032 |
| 懷孕分級 |
|
| 给药途径 | 皮下植入器、陰道環 |
| 藥物類別 | 黃體酯酮 (藥物); 黃體素 |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
|
| 藥物動力學數據 | |
| 生物利用度 | 植入：100%[4] 陰道環：100%[5] |
| 血漿蛋白結合率 | ≥98%（66%與白蛋白，32%與性激素結合球蛋白）結合[4] |
| 药物代谢 | 肝臟（CYP3A4）[4][5] |
| 生物半衰期 | 21–38小時[6][7][8][4][5] |
| 排泄途徑 | 尿（主）、糞便（少）[4][5] |
| 识别信息 | |
| |
| CAS号 | 54048-10-1  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.053.561 |
| 化学信息 | |
| 化学式 | C22H28O2 |
| 摩尔质量 | 324.46 g·mol−1 |
| 3D模型（JSmol） | |
| |
| |
依托孕烯（英語：Etonogestrel）是一种人工合成的甾体有机化合物，化学式C22H28O2，可作为依托孕烯植入器的药物用于女性避孕[9]
參考文獻
- ^ Ryan KJ. Kistner's Gynecology and Women's Health. Mosby. 1999: 300. ISBN 978-0-323-00201-1.
- ^ NEXPLANON : Etonogestrel extended release subdermal implant (PDF). Pdf.hres.ca. [2022-06-08]. （原始内容存档 (PDF)于2022-06-10）.
- ^ List of nationally authorised medicinal products : Active substance: etonogestrel : Procedure no.: PSUSA/00001331/202109 (PDF). Ema.europa.eu. [2022-06-08]. （原始内容存档 (PDF)于2022-06-10）.
- ^ 4.0 4.1 4.2 4.3 4.4 Nexplanon- etonogestrel implant. DailyMed. 18 November 2019 [25 September 2020]. （原始内容存档于10 June 2022）.
- ^ 5.0 5.1 5.2 5.3 NuvaRing- etonogestrel and ethinyl estradiol insert, extended release. DailyMed. 24 January 2020 [25 September 2020]. （原始内容存档于8 August 2020）.
- ^ Runnebaum BC, Rabe T, Kiesel L. Female Contraception: Update and Trends. Springer Science & Business Media. 6 December 2012: 156–163. ISBN 978-3-642-73790-9.
- ^ Holtsclaw JA. Progress Towards the Total Synthesis of Desogestrel and the Development of a New Chiral Dihydroimidazol-2-ylidene Ligand. University of Michigan. 2007: 25.
In 1981, desogestrel was marketed as a new low dose oral contraceptive under the trade names Marvelon and Desogen.32
- ^ Mosby's GenRx: A Comprehensive Reference for Generic and Brand Prescription Drugs. Mosby. 2001: 687. ISBN 978-0-323-00629-3.
The elimination half-life for 3-keto-desogestrel is approximately 38 ± 20 hours at steady state.
- ^ Borsch, Julia. [www.deutsche-apotheker-zeitung.de/news/artikel/2017/08/14/verhuetungsringe-jetzt-auch-ungekuehlt Verhütungsringe jetzt auch ungekühlt] 请检查
|url=值 (帮助). DAZ.online. 2017-08-14.